Impact of Biological Sex and Sex Hormones on Molecular Signatures of Skeletal Muscle in Response to Exercise Training

This session will explore cutting-edge research on sex differences in hormone actions, shedding light on how biological sex influences metabolic and physiological responses. The presentations will delve into the sex-specific effects of thyroid hormone receptor ß signaling on metabolism during high-fat diet consumption in mice, revealing potential mechanisms behind sex-based differences in metabolic disorders. Additionally, the session will examine the distinct actions of estradiol and dihydrotestosterone in human systems, offering insights into hormone-driven cellular responses. Finally, the impact of biological sex and sex hormones on skeletal muscle molecular signatures following exercise training will be discussed, highlighting the role of sex in exercise physiology. By investigating these diverse aspects, the session aims to deepen our understanding of sex-based variations in hormone actions and their implications for health, disease, and personalized medicine.

Sex-Specific Actions of Estradiol and Dihydrotestosterone in Primary Human Cell Cultures and Microphysiological Systems

Mark J Mondrinos, Ph.D.

Tulane University

Sex-Specific Effects of THRβ Signaling on Metabolic Responses to High Fat Diet in Mice

Subburaman Mohan, PhD

VA Loma Linda Healthcare Systems

Chair

Jen-Chywan Wang, PhD

UC Berkeley

Impact of Biological Sex and Sex Hormones on Molecular Signatures of Skeletal Muscle in Response to Exercise Training

K Sreekumaran Nair, MD,PhD

Mayo Clinic

Chair

Carolyn L Cummins, PhD

University of Toronto