Structural Analysis into PPARγ Inverse Agonism Reveals a Novel Nuclear Receptor Regulatory Mechanism

This session will cover new insights into steroid hormone receptor signalling based on structural biology. Mechanisms of agonism and antagonism at the TSH receptor, mineralocorticoid receptor and PPARɣ receptors will be explored.

Structural Analysis into PPARγ Inverse Agonism Reveals a Novel Nuclear Receptor Regulatory Mechanism

Douglas Kojetin, PhD

Vanderbilt University

Structural Basis of Agonism and Antagonism at the Mineralocorticoid Receptor

Peter J Fuller, AM, BMedSci(Hons), MBBS,PhD, FRACP

Hudson Institute of Medical Res

Chair

Sean William Fanning, PhD

LOYOLA UNIVERSITY

New Insights into the TSH Receptor

Aashish Manglik, MD, PhD

University of California San Francisco

Chair

Kristy A Brown, PhD

UNIVERSITY OF KANSAS MEDICAL CENTER