Microbiome, Metabolome and Obesity in Adolescents with PCOS

Bulent Okan Yildiz, MD

Hacettepe University School of Medicine

Abstract

Richard S Legro, MD

Penn State University College of Medicine

Abstract

Vasantha Padmanabhan, MS,PhD

University of Michigan

Abstract

Melanie -- Cree-Green, MD, PhD

University of Colorado and Children's Hospital Colorado

Abstract

Polycystic ovary syndrome (PCOS) is a multi-system chronic disease in which metabolic and reproductive derangements are intertwined, and pathogenic alterations in the gut microbiome are part of the problem. Recent studies have defined the molecular mechanisms through which perturbations in the PCOS microbiome and energy-sensing hormones affect the functions of the hypothalamic-pituitary-ovarian axis and, ultimately, fertility. This symposium will focus on recent advances in our knowledge of the mechanisms underlying the gut-brain axis signaling in PCOS, disruptions in the gastrointestinal immune system, and outcomes of dietary and hormonal interventions in this aspect of PCOS.

Barbara Maria Obermayer-Pietsch, MD

Medical University Graz

Abstract

Nanette F Santoro, MD

University of Colorado School of Medicine

Abstract