Cancer Risk in GH Deficiency and Excess: GH, IGF1 System, and Carcinogenesis
Cesar Luiz Boguszewski, MD,PhD
Sempr Fed University Parana
The association between GH-IGF system and carcinogenesis has long been investigated. The rationale is based on that several components of the GH-IGF system have important roles in the regulation of cell proliferation, differentiation, apoptosis and angiogenesis. Epidemiological, genome-wide association and clinical studies have examined the association between GH-IGF with the most common types of malignancies, In animal and human models, genetic defects associated with GH deficiency or resistance are associated with protection from tumor development, while risk of malignancies in acromegaly or in patients exposed to recombinant GH therapy has long been a matter of concern and scrutiny. In this session, a narrative review covering the potential relations between GH-IGF axis and cancer will be presented and debated based on different clinical scenarios.