Comprehensive Approach to Male Infertility and Subfertility: Endocrinological and Surgical Perspectives
Robert McLachlan, MD, PhD
Hudson Institute of Medical Research
World Health Organization estimates that about 10 % couples struggle with problems of infertility and subfertility; a male factor contributes to approximately 30 to 50 % cases of couple infertility. Optimal spermatogenesis requires synergistic actions of androgens and FSH. Both testosterone and FSH facilitate normal Sertoli cell morphology and function as well as germ cell survival and proliferation. Male infertility and subfertility can result from various anatomical and genetic abnormalities, hormonal issues, systemic and neurological problems, trauma, infective diseases, gonadotoxic agents and various environmental factors and anti-sperm antibodies. Though various factors in male subfertility remain unclear and untreatable, various conditions can be treatable including secondary hypogonadism, infections, obstructions, and surgical conditions like varicocele. This session's first part will discuss role of endocrinologist in medical management of male subfertility while the second section will discuss surgical perspectives of male subfertility and available treatments.
Robert McLachlan, MD, PhD
Hudson Institute of Medical Research
Vaibhav Modgil, BM MSc FRCS (Urol)
Manchester Andrology Centre
Shaishav Dhage, MBBS, DNB (Medicine), MRCP, MD
The Christie NHS Foundation Trust